Abstract
In Reply.— Dr Richart asserts that advances in our knowledge about the morphological appearances of HPV could have led to bias in the National Collaborative Diethylstilbestrol Adenosis Project study, in which tissue slides have been analyzed since 1976. 1 Although some bias is possible, we believe it to be minimal since the slides disclosing dysplasia were reviewed by all pathologists and cytologists, and many slides were rereviewed periodically over a period of years as part of quality-control procedures. A major problem facing all pathologists and cytologists today is in fact the diagnostic criteria distinguishing HPV lesions from dysplasia and carcinoma in situ (collectively, Richart's CIN). Do lesions exhibiting both koilocytosis and marked nuclear atypia represent one disease state or both simultaneously? We have demonstrated that such lesions may have HPV demonstrable by immunoperoxidase stains while also demonstrating aneuploidy by microspectrophotometric analysis of Feulgen-stained slides. 2 We believe that many lesions
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
More From: JAMA: The Journal of the American Medical Association
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.