Abstract
Objective: In the current study, we investigated the incidence of acute kidney injury (AKI) induced by cardiac arrest (CA) and cardiopulmonary resuscitation (CPR) and whether such an AKI can recover spontaneously in rats.Methods: We used transesophageal alternating current stimulation to establish 7 min of CA rat model followed by conventional CPR. The experimental rats were randomly divided into three groups (n = 20 per group) according to the different time points after restoration spontaneous circulation (ROSC): the ROSC 24 h, ROSC 48 h, and ROSC 72 h group. The diagnosis of rat AKI refers to the 2012 KDIGO adult AKI diagnostic criteria. The severity of AKI quantified by the serum creatinine (SCR), blood urea nitrogen (BUN) levels and histological features of renal tissue.Results: The incidence rates of AKI in ROSC 24 h, ROSC 48 h, and ROSC 72 h group were 65%, 45%, and 42.9%. Moreover, the values of SCR and BUN were highest at ROSC 24 h, and then gradually decreased with the time of ROSC. The histological changes of the renal tissues such as glomerular collapse, renal tubular cell swelling, and inflammatory cell infiltration had also observed.Conclusion: The incidence of AKI in rats was high after suffering from CA and CPR, but renal function improved with the prolongation of ROSC time, indicating the ability of the kidney to self-repair.
Highlights
Acute kidney injury (AKI), previously called acute renal failure (ARF) [1], is caused by a variety of causes, including renal ischemia-reperfusion injury (IRI), and the Whole-body ischemia-reperfusion injury (WBIRI) was one of the most common causes of AKI after cardiac arrest (CA) [2]
Even if the first phase of resuscitation is successful after CA and cardiopulmonary resuscitation (CPR), all organs of the body suffer from WBIRI damage due to restoring spontaneous circulation (ROSC), resulting in multiple organ dysfunction syndromes (MODS) [3]
Our results showed that not all the rats experienced CA/CPR met the diagnostic criteria of AKI
Summary
Acute kidney injury (AKI), previously called acute renal failure (ARF) [1], is caused by a variety of causes, including renal ischemia-reperfusion injury (IRI), and the Whole-body ischemia-reperfusion injury (WBIRI) was one of the most common causes of AKI after cardiac arrest (CA) [2]. Several studies have found that AKI was a common post-resuscitation syndrome that develops in approximately 30% of inhospital cardiac arrest patients [4], While the incidence of AKI stage 3 occurred in out-of-hospital cardiac arrest (OHCA) patients was 48.3% [5]. To investigate how many cases of AKI do occur following CA and CPR.
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