Abstract
Summary 1. Six hundred four children, aged 7 to 60 months, were examined for qualitative urinary coproporphyrin III. 2. Positive coproporphyrin of 2 plus or more was found in 197. 3. Blood lead determinations, x-rayof long bones, hematologic examinations, and a complete history and a careful physical examination were done on all those with positive coproporphyrinuria and in 136 subjects with negative coproporphyrinuria. 4. The mean blood lead for the two group was 0.043 mg. per cent. 5. The upper limit of normal blood lead seems to be 0.05 mg. per cent as at this value and above there was an increase in symptoms and findings ascribed to lead intoxication, though serious lead intoxication can in some individuals occur at lower values. 6. There was no significant difference of blood lead or other findings of lead intoxication in the patients with or without coproporphyrinuria. 7. Abnormal blood lead values were found in 44.4 per cent of the 333 children studied. 8. A history of pica was noted in69.6 per cent of the children with a blood lead of 0.05 mg. per cent or higher. This one finding gave higher correlation with blood lead than any other single test or symptom. 9. These findings suggest that childrenliving in other metropolitan areas where lead paint has been used in the house for many years should be investigated for evidences of lead poisoning.
Published Version
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