The incidence and risk factors associated with the retinopathy of prematurity in a tertiary hospital using 10-year retrospective data.

Abstract

The study aimed to examine the incidence and risk factors associated with retinopathy of prematurity at Phramongkutklao Hospital. A retrospective review was conducted on the medical records of premature infants screened for retinopathy of prematurity between January 2011 and December 2021. The screening examination was performed on infants who met the screening criteria, and retinopathy of prematurity was diagnosed according to the International Classification of Retinopathy of Prematurity. Maternal, obstetric, neonatal, and medical data were retrieved. Logistic regression analysis was used to identify the risk factors associated with retinopathy of prematurity. A total of 403 premature infants were screened. The mean ± SD birth weight and gestational ages were 1,538 ± 543 grams and 31 ± 3 weeks, respectively. The incidence of any retinopathy of prematurity and stages 2 and 3 were 13.6%, 3.5%, and 10.1%, respectively. Multiple logistic regression analysis demonstrated that gestational age (adjusted odds ratio = 1.98, 95% CI:1.15-3.39), low birth weight (adjusted odds ratio = 0.99, 95% CI: 0.99-1.00), and phototherapy (adjusted odds ratio = 0.41, 95% CI: 0.17-1.00) were significant factors associated with the development of retinopathy of prematurity, after controlling for other confounding factors. The incidence of total retinopathy of prematurity cases in this population was 13.6%. Overall, retinopathy of prematurity cases classified as stage 2 equated to 3.5% and stage 3 to 4.1%. Our data suggest that factors associated with retinopathy of prematurity consist of birth weight, gestational age, and phototherapy.