The incidence and outcome of sepsis and septic shock at intensive care unit of first central hospital of Mongolia

Abstract

Introduction: Sepsis represents a significant socioeconomic burden worldwide. Information about sepsis in Mongolia remains rare and insufficient. Objectives: The purpose of this study was to determine the incidence and outcome for sepsis by admissions to the mixed intensive care unit (ICU) of First Central Hospital of Mongolia (FCHM), as well as independent predictors of mortality. Methods: We performed a 6 month, closed, retrospective, observational cohort study in the ICU of FCHM. All admissions into the mixed intensive care unit (MICU), from September 2017 to March 2018 were screened and patients with sepsis or septic shock were included. Cases with an incomplete record, death or discharge from ICU earlier than 24h and documentation of do not resuscitate orders within 24h of admission were excluded from the study. In case of readmission, only the first admission was considered. All statistical analyses were performed with the software Stata-12. Results: A total of 114 patients, 34.6% of ICU admissions were diagnosed with sepsis (n = 50) or septic shock (n = 64) according to specific clinical criteria and were included into this study. Patients admitted to the ICU were predominantly female (53.5%), average age was 48.3±18.4 years. The most frequent sites of infection were soft tissue infection and urinary-tract infection. The overall intensive care unit mortality was 32.87% but the mortality from the sepsis-group was 55.2% compared to 22.3% for the non-sepsis group. Through a logistic regression, the presence of lung infection (OR, 2.8; 95%CI, 1.0–7.7) had a significant association with mortality whereas the presence of soft tissue infection had a low associated with mortality. Conclusion: The incidence of sepsis and septic shock were common in our ICU with high mortality and can be of help to know more about sepsis and septic shock in Mongolia.