Abstract
Early detection of the connective tissue dysplasia (CTD) is hampered as the used diagnostic criteria are complex and subjective. The aim of the study is to examine the incidence and clinical profile of the adolescent CTD by means of the screening checklist. Methods. The study included the pupils at the age of 10–14 years. The questionnaire designed to reveal the 7 CTD’s signs (thin skin, skin hyperelasticity, keloid cicatrix, blue sclera, soft auricles, arachnodactylia, joints hypermobility), containing 12 illustrated questions with explanation for the parents, was performed as a screening method. The conditionally healthy group (the absence of CTD) consisted of the adolescents with below 12 points total and CTD group was presented by the adolescents with 13 and more points. The physical development was appreciated according to the centile tables, Quetelet index and Vargui index. The health status analysis was based on the out-patient medical records. Results. 1560 pupils were the participants of the study: 752 boys (48.2%) and 808 girls (51.8%). CTD signs were observed in 965 (61.9%) children. The adolescents with CTD’s signs demonstrated the following characters more often than the adolescents without CTD’s signs: soft auricles — 788 (81.7%) against 277 (46.6%), skin hyperelasticity — 685 (71%) against 93 (15.6%), joints hypermobility — 665 (68.9%) against 203 (34.1%), blue sclera — 665 (68.9%) against 184 (30.9%), arachnodactylia — 534 (55.3%) against 57 (9.6%). The disharmonious physical development because of the underweight body took place in 430 (52.3%) adolescents with CTD. Compared to the conditionally healthy group the most of the adolescents with CTD had the pathology of the musculoskeletal system (scoliosis, flatfoot), myopia, vegetative-vascular dystonia, digestive apparatus diseases. The CTD is associated with greater probability of the development of above mentioned pathologies, that can be indicative of the contribution of the anomalies of the connective tissue development into the etiopathogenesis of the these diseases. Conclusion. It is established that there is the high prevalence of the CTD signs among the adolescents (pupils) at the age of 10–14 years.
Highlights
Detection of the connective tissue dysplasia (CTD) is hampered as the used diagnostic criteria are complex and subjective
The conditionally healthy group consisted of the adolescents with below points total and CTD group was presented by the adolescents with and more points
The adolescents with CTD’s signs demonstrated the following characters more often than the adolescents without CTD’s signs: soft auricles — 788 (81.7%) against 277 (46.6%), skin hyperelasticity — 685 (71%) against 93 (15.6%), joints hypermobility — 665 (68.9%) against 203 (34.1%), blue sclera — 665 (68.9%) against 184 (30.9%), arachnodactylia — 534 (55.3%) against 57 (9.6%)
Summary
Раннее выявление дисплазии соединительной ткани (ДСТ) затруднено, так как используемые критерии диагностики сложны, субъективны. Цель исследования — изучить распространенность и клиническую характеристику ДСТ у подростков при помощи скринингового вопросника. Установлена высокая распространенность признаков ДСТ среди подростков (учеников) в возрасте 10–14 лет. (Для цитирования: Калаева Г.Ю., Хохлова О.И., Деев И.А., Самойлова Ю.Г. Распространенность и клиническая характеристика дисплазии соединительной ткани у подростков. Цель исследования — изучить распространенность и клиническую характеристику ДСТ у подростков с использованием скринингового вопросника. Исходы исследования Определяли распространенность ДСТ и факторы, ассоциированные с наличием ДСТ у детей и подростков в возрасте 10–14 лет. Методы регистрации исходов Оценка признаков ДСТ Анкетирование участников исследования выполнено с помощью диагностического вопросника, разработанного нами ранее Вопросник для скрининга дисплазии соединительной ткани у детей и подростков Table 1. Имеются ли у ребенка видимая сосудистая сеть (на груди, спине, конечностях), тонкая кожа
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