The Inaugural Use of Gene Editing for the Study of Tumor Suppressor Pathways in Human Cells-p21WAF1/CIP1.

Abstract

See related article Waldman et al., [Cancer Res 1995;55:5187–90][1] . Visit the Cancer Research 75th Anniversary [timeline][2]. By the early to mid-1990s it was becoming increasing clear that cancer was in large part a loss-of-function disease, caused by inactivating mutations in tumor