The inappropriate use of proton pump inhibitors and its associated factors among community-dwelling older adults

Mohammad Rababa,Abeer Rababa'H

doi:10.1016/j.heliyon.2021.e07595

Mohammad Rababa, Abeer Rababa'H

Open Access

https://doi.org/10.1016/j.heliyon.2021.e07595

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Journal: Heliyon	Publication Date: Jul 1, 2021
Citations: 7	License type: cc-by

Affiliation: Jordan University of Science and Technology

Abstract

ObjectivesLittle is known about the inappropriate use of proton pump inhibitors (PPIs) and how mild cognitive impairment (MCI) and high comorbid burden relate to the inappropriate prescribing of PPIs. Therefore, the current study aimed to examine these associations among community-dwelling older adults in Jordan. MethodThis cross-sectional study was conducted on 215 community-dwelling older adults from three local healthcare centers located in Irbid, Jordan. Data about PPI use, including the name of medication, dose, frequency, duration, and indication, were collected retrospectively from a review of the participating older adults’ medication cards for November and December 2019. The collected data were evaluated based on the Food and Drug Administration (FDA) guidelines. MCI was measured using the Arabic version of the Montreal Cognitive Assessment, and comorbid burden was measured using the Cumulative Illness Rating Scale for Geriatrics. ResultsForty-seven percent of the participants were found to have taken a PPI, with 68 % having taken one for a longer period than recommended by the FDA. Older adults with MCI or high comorbid burden were found to be more susceptible than other older adults to the long-term use of PPIs. The logistic regression revealed that MCI is a statistically significant predictor of inappropriate PPI use (p < 0.001). ConclusionInappropriate PPI use is common among community-dwelling older adults in Jordan, with a significantly higher prevalence of inappropriate PPI use in people with MCI than in people with normal cognitive abilities. Future intervention studies are highly recommended to encourage optimal prescribing of PPIs for community-dwelling older adults.

Highlights

The inappropriate prescribing of medications is prevalent among older adults, a population with multiple comorbidities, cognitive impairments, and communication deficits [1]
The current study focused on examining the possible association between older adults whether having mild cognitive impairment (MCI) or not and the risk of them being inappropriately prescribed pump inhibitors (PPIs)
The current study found PPI use to increase with body mass index (BMI)

Summary

Introduction

The inappropriate prescribing of medications is prevalent among older adults, a population with multiple comorbidities, cognitive impairments, and communication deficits [1]. This high prevalence is due to age-related physiological changes that affect homeostasis, pharmacokinetics, and pharmacodynamics in older adults [2]. Many studies have reported the inappropriate prescribing of medications among community-dwelling older adults in both Western and Eastern countries [4, 5]. To the researchers’ knowledge, a very limited number of studies has examined the inappropriate prescribing of medications among community-dwelling older adults in Jordan [6, 7]

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