Abstract
Wound is defined as primarily damaged or disruption of skin contributed to the loss of its microstructure stability and which undergoes complex wound healing process. However, there are tons of factors that could affect the wound healing process such as infection and slow angiogenesis. Involvement of nanotechnologies therapies in wound care research aims to facilitates this healing process. Quantum dots (QDs) are an advanced nanomaterial technology found to be useful in clinical and biomedical applications. This review has been carried out to provide a summary of the application of QDs in acute or chronic wound healing. A thorough searching was done via Web of Science and SCOPUS database to obtain relevant articles including the in vivo, in vitro and in ovo studies. The results demonstrated a similar effect of different types of QDs, or an improvement of QDs in wound healing, antibacterial and angiogenesis properties. This review demonstrated the effectiveness of QDs for the wound healing process mainly by their antibacterial activity. Uniquely, the antibacterial effect unraveled an increasing trend over time influenced by the various concentration of QDs. In conclusion, the application of QDs support the wound healing phases and proven to be effective in vivo, in vitro and in ovo. However, the future QDs work should focus on the molecular level for the details of cellular interactions and pathways.
Highlights
Skin is the largest organ of the body which acts as a front-liner of defense mechanism [1]
Data collected throughout this review shows that quantum dots (QDs) assisted in the acceleration of the wound healing process by eliminating microbial infection and promote angiogenesis
The use of QDs together with advanced technology of biomaterials could synergistically expedite wound care management worldwide. Studies included in this overview have shown the efficiency of the application of quantum dots (QDs; derived from a different type of sources) in biomedical applications due to their wound healing, antimicrobial, and angiogenesis properties
Summary
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