The in vivo Expression of Gamma secretase catalytic subunit (presenilin) in patients with chronic lymphocytic leukemia

Abstract

Background:Gamma secretase is an intramembranous protease that plays an important role in NOTCHpathway that has a central role in malignancies Aim and objectives: The Aim of this work is to evaluate the in vivo expression of gamma secretase catalytic subunit (Presenilin) in patients with B cell lymphocytic leukemia. Subjects and Methods: This is a cross sectional study, was carried out at Internal medicine department, clinical hematology inpatient unit and outpatient department (OPD),Ain Shams University Hospitals. On 30 patients with chronic lymphocytic leukemia, between 2020 and 2021 Result:There was high statistically significant correlation between the gamma secretase catalytic subunit presenilin expression with type of patients being higher in relapsed and resistant cases than newly diagnosed.There was high statistically significant difference between the patient and healthy group as regard the gamma secretase gene catalytic subunit presenilinexpression Conclusion The gamma secretase catalytic subunit(presenilin) expression in cLL patients was elevated in comparision to healthy individuals and was elevated in resistant- relapsed cLL patients in comparision to newly diagnosed individuals and that will add prognostic role.So, gamma secretase inhibitors could be a light path as a line of therapy