Abstract
Irvin A. D., Young E. R. and Purnell R. E. 1978. The in vitro uptake of tritiated nucleic acid precursors by Babesia spp. of cattle and mice. International Journal for Parasitology 8: 19–24. Blood and mice infected with Babesia microti and B. rodhaini, and from cattle infected with B. divergens and B. major, was incubated in Eagles medium for 24 h in the presence of tritiated purines and pyrimidines. Uptake of these compounds was assessed by liquid scintillation counting and by autoradiography. Hypoxanthine, adenosine and adenine were readily incorporated by all four species of parasites. Thymine, thymidine and uridine were generally not incorporated. Uptake of [ 3H]hypoxanthine by B. microti occurred within minutes of exposure to the precursor. The amount of [ 3H]hypoxanthine incorporated by B. rodhaini-infected erythrocytes was proportional to the percentage of parasitized cells The results suggest that structural analogues of hypoxanthine and other purines may be incorporated and act against intra-erythrocytic Babesia.
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