Abstract
The in vitro resistance of 40 strains of Staphylococcus aureus isolated from dogs to trimethoprim, sulphamethoxazole and co-trimoxazole (SXT) was assessed using the disc diffusion technique on Diagnostic Sensitivity Test Agar (DSTA), DSTA with 5% lysed horse blood (DSTA + B), IsoSensitest Agar (ISTA) and Wellcotest Sensitivity Test Agar (WSTA). When sensitivity was based on a zone width of greater than or equal to 4 mm all 40 strains were sensitive to SXT on DSTA + B and ISTA, 39 were sensitive on WSTA while only 31 (77.5%) were sensitive on DSTA. A comparison of the results obtained for each strain for trimethoprim and sulphamethoxazole with those obtained with the Oxford strain of S. aureus and using a scheme for interpretation recommended by Garrod & O'Grady (1971) indicated that the proportion of strains classed as sensitive for therapeutic purposes was 5%, 55%, 47.5% and 15% respectively on DSTA, DSTA + B, ISTA and WSTA.
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