Abstract
In the chicken, duck, turkey and rabbit, about two-thirds of the hepatic aflatoxin-metabolizing activity is located in a soluble fraction obtained after centrifuging liver homogenates in 0.15 m-KCl at 105,000 g. Little or no activity is present in the same fraction obtained from guinea-pig, mouse and rat livers. Evidence is presented which strongly suggests that aflatoxins B 1 and B 2 are reduced in vitro by NADP-dependent enzymes of chicken and duck livers to form the corresponding cyclopentenols, aflatoxicol and dihydro-aflatoxicol. This metabolic pathway was not previously recognized because these products are easily confused with the parent aflatoxins on thin-layer chromatograms.
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