Abstract
The in vitro neuromuscular blocking properties of a sea snake ( Enhydrina schistosa) venom have been investigated in a variety of skeletal muscle preparations and compared with those of d-tubocurarine and diallylbisnortoxiferine. Seven different muscles were examined ranging from the monkey extraocular to the leech dorsal wall. The blocking properties of the venom, presumably due to the presence of neurotoxins, were markedly different from those of d-tubocurarine and diallylbisnortoxiferine which were very similar to each other. This, and other results, were discussed in terms of the possible sites of action of the venom and identification of the nicotinic cholinoceptor.
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