Abstract
Background Nowadays, Type 2 Diabetes Mellitus (T2D) affects a significant percentage of the world population. Due to the high levels of glucose, it causes several damages to the cells and, consequently, to the organism. Plants, such as guarana (Paullinia cupana), which present bioactive compounds, could help somehow in the treatment of diabetes and other chronic diseases. Studies have shown that guarana extract, rich in compounds like methylxanthines, theobromine and theophylline, presents many beneficial effects to the organism, such as antioxidant capacity, modulation of nitric oxide intracellular levels, as well as anti-obesity and anti-inflammatory capacity.
Highlights
Nowadays, Type 2 Diabetes Mellitus (T2D) affects a significant percentage of the world population
The in vitro effect of guaraná (Paullinia cupana) extract on human peripheral blood mononuclear cells exposed to a high glucose level
Guaraná presented a cytoprotective effect on the cellular viability at all tested concentrations, including the cells treated with glucose (Fig. 2)
Summary
Type 2 Diabetes Mellitus (T2D) affects a significant percentage of the world population. Due to the high levels of glucose, it causes several damages to the cells and, to the organism. Plants, such as guaraná (Paullinia cupana), which present bioactive compounds, could help somehow in the treatment of diabetes and other chronic diseases. Studies have shown that guaraná extract, rich in compounds like methylxanthines, theobromine and theophylline, presents many beneficial effects to the organism, such as antioxidant capacity, modulation of nitric oxide intracellular levels, as well as anti-obesity and anti-inflammatory capacity
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