Abstract
The formation of incomplete virus by the influenza B/Lee strain on serial undiluted passages in the allantoic cavity has been studied in growth curve experiments with both the allantoic membranes and fluids. It is shown that large amounts of incomplete virus are produced by the B/Lee strain after 5 to 7 undiluted transfers. Comparative studies on the A/PR8 and B/Lee strains show that maximal incompleteness is consistently attained in UP-2 to UP-4 with the PR8 strain and in UP-5 to UP-7 with the Lee strain indicating that the pattern of behavior is an inherent characteristic of the strains. The Lee strain is found to be capable of eliciting at least the same amounts of incomplete virus as is the PR8 strain and this vitiates the sequence of the strains in the “incomplete virus gradient” suggested byFazekas de St. Groth andGraham, and makes its existence questionable.
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