Abstract
Extracts of B. javanica have been used for years in traditional medicine and have been evaluated scientifically as well. Nano-sized drugs have a high ability to penetrate cells and can be manufactured without the use of heat. This study compared the physiological effect of nano herbal Sikkam leaves (NSL) to an ethanol extract of Sikkam leaves (EESL) in blood, kidney, liver, and urine. The NSL was created through high-energy milling. The chemical components of the NSL were determined using thin-layer chromatography. The 2,2-Diphenyl-1-picrylhydrazyl method was used to conduct antioxidant tests. By giving NSL and EESL at doses of 800, 1300, 2000, and 3200 mg/kg during 14 weeks, the mice's blood was collected for the hematological parameters, kidney and liver for the biochemical parameters, and urine for the electrolyte parameters. The diameter of the NSL was 188.8 nm ± 42, and the IC50 level was 28.24 μg/mL (very strong). NSL did not significantly change the number of blood cells, decreased the liver biochemical parameters, and decreased the number of electrolytes in urine better than EESL. NSL provides a better physiological effect compared to ethanol extract preparations
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