The improvement effects of Orengedokuto for aggression and violence to caregiver’s care from patients with dementia

Abstract

AbstractBackgroundBehavioral and psychological symptoms of dementia (BPSD) increase the distress of patients with dementia and the burden for care givers and they are the symptoms that need to be solved immediately. Antipsychotics are not recommended for the treatment of aggression and violence in BPSD, because they make the risk of death of the elderly according to Food and Drug Administration (FDA, 2005). So, as a medicine with less side effects which give the expected effect, herbal medicine is used often for BPSD in Japan. We have focused on Orengedokuto within Japanese herbal medicine, and reported that it improve the aggression (Urabe et al., AAIC2019) and behavioral deviation and the rejection of care by patients with dementia ((Urabe et al., AAIC2020) in AD. The purpose of this research is to clarify the effect of Orengedokuto to aggression and violence of patients with dementia.MethodThe subjects were 11 patients with dementia admitted to a psychiatric hospital in Japan. The group of the patients with dementia who were administered with Orengedokuto (ODG;8 patients, average age ; 83 years old) and a control group of the patients with dementia who did not take Orengedokuto (NODG; 3 patients, average age; 80.3 years old). We evaluated the patients with Behavioral Pathology in Alzheimer’s disease (Behave‐AD), Mini Mental State Examination, the improvement effects of aggression and violence were compared the changes before and after administration between ODG and NODG. There is no conflict of interest in this study.ResultThe average score of aggression and violence, was 7.25 point (before administration: before) to 1.5 point (at the time of leave from hospital: after) in ODG (p<0.05), and 7.6 point (before) to 4.6 point (after) in NODG.ConclusionIn ODG, aggression and violence behavior was improved. It was clarify that Orengedokuto has the improve effect of aggression. And it was suggested that Orengedokuto has the improve effect of violence behavior related aggression, too.