Abstract
HIGHLIGHTS The main characteristic of SARS-CoV, MERS-CoV and SARS-CoV-2 is that air passes through the upper respiratory tract The tissue of the upper respiratory tract can express both ACE2 and TMPRSS2. AR is abundantly expressed in lungs. TMPRSS2, ACE2, and AR connection explains why high expression of AR gene is present in the male lung.
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