Abstract
IntroductionThe aim of this study was to examine the influence of weight change experiences over time on motivation to perform diabetes self-care behaviors using data from a study of canagliflozin (an agent that inhibits sodium glucose co-transporter 2) versus glimepiride in dual therapy with metformin and background diet/exercise.MethodsWeight and motivation for performing healthy behaviors were collected at baseline and over time. The motivation questionnaire enabled categorization into two groups: those performing or not performing health behaviors. Four distinct patterns of weight change were determined: losing weight, gaining weight, and two patterns for fluctuating weight. The relationships between these patterns and motivation for weight loss, following a diet, and exercise were examined using logistic regression models.ResultsOf 1182 subjects, more than half were already performing behaviors to lose weight, diet, and exercise at baseline. Among those who were not, 52% (246/474) started taking action to lose weight after baseline, 54% (241/448) started following a diet, and 42% (232/556) started exercising. Weight change patterns were significantly related to performance of healthy behaviors at follow-up (week 36). Compared to the weight gain pattern, those who experienced a continuous weight loss pattern from baseline to week 36 were 2.2 (95% confidence interval 1.49, 3.37) times more likely to perform the healthy behaviors. Baseline behavior and confidence were also predictive of performing healthy behaviors.ConclusionThe current work highlights the importance of weight change patterns for performance of diabetes self-care. Tracking weight patterns over time, assessing confidence for performance of healthy behaviors, and being aware of the relationship between weight changes and diabetes self-care behaviors are viable, concrete ways to practice patient-centered care.FundingJanssen Global Services, LLC.Electronic supplementary materialThe online version of this article (doi:10.1007/s13300-015-0145-8) contains supplementary material, which is available to authorized users.
Highlights
The aim of this study was to examine the influence of weight change experiences over time on motivation to perform diabetes self-care behaviors using data from a study of canagliflozin versus glimepiride in dual therapy with metformin and background diet/exercise
The current work highlights the importance of weight change patterns for performance of diabetes self-care
This analysis is based on results from a 104-week, randomized, double-blind, Phase 3 study that assessed the efficacy and safety of canagliflozin 100 and 300 mg versus maximally tolerated doses of glimepiride in subjects with type 2 diabetes inadequately controlled with metformin and background diet and exercise [22, 23]
Summary
The aim of this study was to examine the influence of weight change experiences over time on motivation to perform diabetes self-care behaviors using data from a study of canagliflozin (an agent that inhibits sodium glucose co-transporter 2) versus glimepiride in dual therapy with metformin and background diet/exercise. Woo Axio Research, Seattle, WA, USA fluctuating weight The relationships between these patterns and motivation for weight loss, following a diet, and exercise were examined using logistic regression models. Compared to the weight gain pattern, those who experienced a continuous weight loss pattern from baseline to week 36 were 2.2 (95% confidence interval 1.49, 3.37) times more likely to perform the healthy behaviors. Tracking weight patterns over time, assessing confidence for performance of healthy behaviors, and being aware of the relationship between weight changes and diabetes self-care. Self-care behaviors, such as following a healthy diet, being physically active, taking medications as prescribed, and monitoring health (e.g., glucose levels, body weight, blood pressure) [1], are an important part of achieving optimal outcomes and can have a major impact on the lives of patients, their families, and society [2]. Drawbacks associated with treatments may deter performance of healthy behaviors
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