Abstract
This case control study investigated the serum and synovial fluid adiponectin levels in 33 patients with rheumatoid arthritis (RA) and 26 patients with osteoarthritis (OA) as the control group.A venous blood sample was collected from each patient in fasting condition to measure plasma adiponectin. At the same time, synovial fluid was aspirated aseptically from the swollen knee joint of all patients and controls. Blood and synovial fluid samples were centrifuged at 5,000 rpm for 5 min, then frozen and stored at -20 °C. For analysis of data, the independent t test, Mann-Whitney test, Kolmogorov-Smirnov test, Pearson’s correlation, and linear regression analysis were utilized.Serum and synovial fluid adiponectin levels were significantly higher in RA patients than OA subjects (P valueThe present study revealed that adiponectin levels were increased in the serum and synovial fluid of RA patients compared with OA patients, and these levels may have a significant role in the pathogenesis of RA.
Highlights
Rheumatoid arthritis (RA) is a chronic systemic autoimmune and destructive disorder characterized by synovial hyperplasia and progressive damage to the articular structure in most patients, which can lead to deformity and dysfunction [1]
Adiponectin may have an important role in the pathogenesis of RA because of the similarity of its two receptors with tumor necrosis factor alpha (TNF_a) [8,9]
It has been shown that adiponectin has a positive correlation with the serum levels of certain inflammatory cytokines such as VEGF, MMP, TNF-a, IL-1ß, IL-6, and IL-8 which are secreted from synovial fibroblasts because of the proinflammatory effect of adiponectin on creating synovitis and its dissociative effect in the intracellular matrix in RA [10,11]
Summary
Rheumatoid arthritis (RA) is a chronic systemic autoimmune and destructive disorder characterized by synovial hyperplasia and progressive damage to the articular structure in most patients, which can lead to deformity and dysfunction [1]. With regard to the proinflammatory effects of adiponectin, in this study, adiponectin levels in the serum and synovial fluid of RA patients were measured and compared with those of OA patients as the control group. Serum adiponectin levels in RA patients were significantly higher than synovial fluid adiponectin levels (P value
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