Abstract
The paper presents the results of studying the anti-ulcer activity of a combination of complex plant extracts on experimental models of stress and acetylsalicylic gastric ulcers when administered per os extract at a dose of 150 mg/ kg to laboratory animals. The experiments were performed on nonlinear male rats and mongrel male mice. Determination of the Pauls index, the anti–ulcer action index (AUE) - the main criteria for evaluating the anti-ulcer activity of drugs. It is shown that in stress ulcers, the effectiveness of the extract is characterized by a decrease in large, point, stripe-shaped ulcers, a decrease in the number of ulcerative lesions in mice, the AUE index = 4.6. It was found that in the acetylsalicylic model of gastric ulcers against the background of the introduction of the extract, ulcers were detected only in 70% of animals, less pronounced damage to the gastric mucosa was observed, the AUE index is 4.5.
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