The importance of mean platelet volume lymphocyte ratio and mean platelet volume platelet ratio in COVID-19 patients

Abstract

Objective: The mean platelet volume lymphocyte ratio (MPVLR) and mean platelet volume platelet ratio (MPVPR) reflect inflammation more effectively and strongly than MPV, lymphocyte, platelet, and neutrophil counts separately, we aimed to evaluate the importance of MPVLR and MPVPR in COVID-19 patients. Material and Methods: Patients with COVID-19 were divided into two groups based on whether their RT-PCR test resulted in a positive or negative result. MPVLR, MPVPR, neutrophil, lymphocyte, platelet, MPV and RDW levels were compared between these two groups. In addition, the changes in MPVLR, MPVPR, neutrophil, lymphocyte, platelet, MPV, and RDW levels before and after treatment were compared in the whole patient population. Results: There were 113 patients diagnosed with COVID-19 with a positive PCR test and 79 patients with a negative PCR test. Before treatment, the MPVLR level was 7.2±0.85 in the PCR test positive group and 5.4±0.29 in the PCR test negative group (p=0.04). Post-treatment MPVLR levels were 5.7±0.4 and 4.9±0.26 in the PCR positive and negative groups, respectively (p=0.09). The MPVPR level before treatment was 0.046±0.002 in the PCR test positive group and 0.035±0.001 in the PCR test negative group (p=0.003). After treatment, the MPVPR level was 0.040±0.002 in the PCR-positive group and 0.032±0.001 in the PCR-negative group (p=0.023) Conclusion: This study is the first to demonstrate high MPVLR and MPVPR in PCR-positive COVID-19 patients. Patients with negative PCR test and high MPVLR and MPVPR should be evaluated with radiological and clinical symptoms.