The importance of Ki-67, PCNA and Progesterone receptor expression in meningiomas

Abstract

Purpose: Meningiomas with their potential biological and clinical behavior represents a broad brand group of tumors. Meningiomas are the most seen benign tumors of the central nervous system and types of atypical and malignant meningioma recurrence rate is high. In recent years, proliferation markers such as Ki-67 and PCNA are commonly used in meningiomas in order to predict recurrence. Materials and methods: In this study, 55 meningioma cases diagnosed in pathology departmant were reclassified according to the WHO 2000 and their histological subtypes and grades were determined. sections from selected paraffin blocks were immunostained with PCNA, Ki-67, EMA, vimentine, and progesterone receptor (PR); and their values in meningioms were investigated. Results: PCNA and Ki-67 values of benign meningiomas are lower than the atypical and malignant meningioms as statistically significant (p<0.05). In addition, the high values of progesterone receptor positivity on benign meningiomas and the lower levels of it on malignant and atypical meningiomas are considered to be statistically significant as well ( p<0.05). Conclusion: PCNA and Ki-67 proliferation rates of atypical and malignant meningiomas are observed to be higher than the benign meningioms. Benign meningiomas with high values of Ki-67 and PCNA should be observed with regard to recurrence although they are completely resected. Progesterone receptor positivity was associated with the differentiation of the tumor and prognosis alone is not enough, however in the differential diagnosis of the tumor was thought to be a good alternative to EMA and vimentine.