Abstract
EHD proteins are membrane remodeling proteins that control exit of receptors from the recycling endosome and their return to the plasma membrane. They consist of a nucleotide binding domain and an EH domain, which is a small Ca2+ binding module composed of 2 EF hands. EH domains bind to asparagine-proline-phenylalanine (NPF) motifs, which are found in various proteins, often in multiple copies, throughout the vesicle trafficking pathway. The mechanism by which EH domains discriminate between individual NPF containing proteins is not well understood.
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