The Importance of Animal Experimentation for Safety and Biomedical Research

Abstract

The necessity of animal experimentation.- Ethical and Legal Aspects.- Animal experimentation defended.- The ethics of animal use in biomedicine.- Legal and political problems of animal experimentation, the 'Swiss battle'.- Experimentation and the law.- Experimentation on animals: animals as machines and animals as fetishes.- Recent Progress of Medicine Requiring the Use of Animals.- The role of animal experiments in pharmacological brain research.- Regeneration of the nervous system.- Endocrine glands, neuroendocrinology and animal experimentation.- Laboratory animals and cardiovascular pathology: means for better use.- The importance of animal models for hypertension research.- Animal experiments and recent progress in thrombosis research.- Models of human renal disease.- The necessity of animal experimentation in tumor immunology.- The use of animals in cancer chemotherapy.- The use of experimental animals in transplantation research.- Animal models for AIDS research.- The need for animal experimentation in drug and vaccine development against tropical diseases.- Use of Animals for Safety Reasons.- Toxicology: role of in vivo studies in establishing mcchanisms of toxicity.- Necessity of animal experiments for the safety evaluation and necessary consequences for public health.- The necessity of animal testing for safety evaluation and medical progress in reproductive biology and toxicology.- The need for animal experimentation in studying the carcinogenic risk of substances.- The Future of Animal Research.- Transgenic animals for human diseases and gene therapy.- Recent progress toward reducing the use of animal experimentation in biomedical research.- Animal use in drug research.