Abstract
6-aminohexanoic acid is an ω-amino acid with a hydrophobic, flexible structure. Although the ω-amino acid in question is mainly used clinically as an antifibrinolytic drug, other applications are also interesting and important. This synthetic lysine derivative, without an α-amino group, plays a significant role in chemical synthesis of modified peptides and in the polyamide synthetic fibers (nylon) industry. It is also often used as a linker in various biologically active structures. This review concentrates on the role of 6-aminohexanoic acid in the structure of various molecules.
Highlights
6-aminohexanoic6-aminohexanoicacid acid(ε-aminocaproic (ε-aminocaproicacid acidand and6-aminocaproic6-aminocaproicacid) acid)isisan anω-amino ω-amino acid acidwith withaahydrophobic hydrophobicand andflexible flexiblestructure structure(Figure (Figure1). 1).DifferentDifferentabbreviations abbreviations of ofits its name are often used in scientific literature (Ahx, EACA, Aca, 6-ACA, Aha and Acp).name are often used in scientific literature (Ahx, EACA, Aca, 6-ACA, Aha and Acp)
The kringle minogen is cleaved by Plg activators, it forms plasmin, the enzyme mainly domains of both Plg and Plm contain “lysine binding sites” (LBS) that interact with lysine responsible for fibrin proteolysis and dissolution of clots in vivo
Traditional modifications of the structure are less suitable for disulfide-rich peptides, as they involve the removal of stabilizing cross-links or of the necessary amino acid residues, leading to a loss of bioactivity
Summary
6-aminocaproicacid) acid)isisan anω-amino ω-amino acid acidwith withaahydrophobic hydrophobicand andflexible flexiblestructure structure(Figure (Figure). Differentabbreviations abbreviations of ofits its name are often used in scientific literature Name are often used in scientific literature (Ahx, EACA, Aca, 6-ACA, Aha and Acp). IUIUPAC recommends that ε-Ahx should generally used in shorter its shorter form: PAC [1][1]. Recommends that ε-Ahx should generally be be used in its form: Ahx.Ahx. The synthetic lysine analog, without an α-amino group, is used clinically as an antifibrisynthetic lysine analog, without an α-amino group, is used clinically as an antifibrinolytic nolytic drug andaplays a role in the chemical synthesis of modified peptides and various drug and plays role in the chemical synthesis of modified peptides and various biologbiologically structures ically activeactive structures [2].
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