Abstract
Abstract : An attempt has been made to relate the protective effect of cortisone against lethality of bacterial endotoxins in mice to changes in activity of liver tryptophan pyrrolase (TP), an enzyme known to be activated by the hormone. In mice maintained at 25 C, TP activity remained normal under conditions associated with survival and diminished in activity when animals were not protected. In addition, nicotinamide and diphosphopyridine nucleotide (DPN) were found to protect mice at 25 C against lethality of endotoxin about as effectively as cortisone. At 5 C, however, mice could not be protected against death from endotoxin by DPN and even cortisone and nicotinamide were less effective than at 25 C. Mice in the cold die sooner than and with different symptoms from those at room temperature.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
