Abstract
The effects of renal glutathione (GSH) depletion on renal injury following a single injection of mercuric chloride (HgCl 2) were evaluated in the rat. Animals were injected with different doses of HgCl 2 and the renal function were studied 1 h later. Diethylmaleate (DEM) (4 mmol/kg body wt, i.p.) induced a significant depletion of GSH by reducing renal GSH levels to 25% of control values. This effect lasted for 6 h. HgCl 2-induced nephrotoxicity, as measured by fractional excretion of glucose, lithium, sodium, potassium and water was increased in rats treated with DEM. The time course of HgCl 2 nephrotoxicity was also investigated by determining the renal function at different times after HgCl 2 and HgCl 2 plus DEM injection. Renal impairment was significantly more marked in rat depleted of GSH.
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