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Abstract
Pancreatic cancer is one of the most aggressive diseases among solid tumors. Most patients are diagnosed with advanced or metastatic disease and are characterized by poor chemosensitivity. Therefore, earlier diagnosis and novel therapeutic possibilities for pancreatic cancer patients are urgently needed. Liquid biopsy is an emerging technology that allows the noninvasive sampling of tumor material. Nowadays, liquid biopsy has shown promising results as diagnostic, prognostic and predictive biomarkers, but it has not yet been universally adopted into regular use by clinicians. In this review, we describe different components of liquid biopsy, especially circulating tumor cells, circulating tumor DNA and exosomes and their potential clinical utility for pancreatic cancer patients.
Highlights
Similar results were presented by Del Re et al.[67], who noticed that pancreatic ductal adenocarcinoma (PDAC) patients undergoing chemotherapy treatment and displaying mutKRAS circulating tumor DNA (ctDNA) increase on the 15th day of therapy had disease progression; the early mutKRAS ctDNA modulation was not associated with tumor response
Pancreatic cancer is among the deadliest solid tumors
We give an overview of the current literature on circulating tumor cells (CTCs), ctDNA and exosomes in pancreatic cancer
Summary
The most common pancreatic neoplasm is pancreatic ductal adenocarcinoma (PDAC), occurring in more www.cdrjournal.com. Tumor components released in body fluids such as circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), vesicles and exosome (EVs) have been studied as predictors of chemoresistance in PDAC [Figure 1]. One of the potential clinical application of liquid biopsies is to identify specific tumor molecular characteristics that could improve the diagnostic process, have prognostic or predictive significance and might be used to determine the potential chemosensitivity or chemoresistance in PDAC patients.
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