Abstract
Electro-acupuncture (EA) applied to both legs for 30 min raised the tail flick latency of the rat significantly. This effect of EA analgesia became attenuated and finally disappeared after repeated EA stimulations, which was termed EA tolerance. EA tolerance and its cross tolerance to morphine analgesia were found to be partially reversed by intracerebro-ventricular injection of 5-hydroxytryptophan (5-HTP), the precursor of 5-hydroxytryptamine (5-HT). However, there was no depletion in cerebral 5-HT, nor was there decrease of the number of 5-HT receptors in the brain of the EA tolerant animals. Results obtained from different lines of analysis point to the conclusion that development of tolerance to profoundly released 5-HT during prolonged EA stimulation may constitute one of the mechanisms for EA tolerance.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Science in China Series B-Chemistry, Biological, Agricultural, Medical & Earth Sciences
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
