Abstract
Weight loss is the mainstay of management for patients with metabolic dysfunction-associated steatotic liver disease. We studied the impact of referral to MOVE!, a nationally-implemented behavioral weight loss program, on weight in MASLD patients. This retrospective cohort study included 102,294 MASLD patients from 125 Veterans Health Administration centers from 2008-2022. Most patients lost no significant weight or gained weight. Increased engagement with MOVE! was associated with greater hazard of significant weight loss compared to no engagement. A minority of patients experienced significant weight loss through 5 years using lifestyle interventions alone.
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