Abstract
Aim: To investigate the impact of time of performance of delayed orchiectomy on overall survival of patients with advanced germ cell tumors of testicle who didn’t undergo surgery before starting of treatment. Materials and methods: From 1986 to 2010 in the department of clinical pharmacology and chemotherapy 71 (4,8%) of 1486 patients underwent delayed orchiectomy. During the first course of chemotherapy (1st group) 39 (55%) patients underwent surgery, 21 (29,6%) patients - during 2nd -4th courses (2nd group), after the ending of chemotherapy – 11 (15,5%) patients (3rd group). Results: Final histological investigation of the specimens revealed viable germ cell tumor in 25 (64,1%) patients in the 1st group, in 10 (47,7%) patients in the 2nd group and no viable tumor in the 3rd group. Conclusion: Performance of orchiectomy simultaneously with the removal of the other sites of the tumor after chemotherapy doesn’t impair survival.
Highlights
Материалы и методы: с 1986 по 2010 года в отделении клинической фармакологии и химиотерапии 71 из 1486 (4,8%) больному выполнена отсроченная ОФЭ
The retrospective analysis was performed to find any impact of time constraints of delayed OE on survival in pts with metastatic germ cell tumor (mGCT)
We analyzed data of 1486 CT-na ve pts with advanced mGCT of testis treated in our department from 1986 to 2010
Summary
We analyzed data of 1486 CT-na ve pts with advanced mGCT of testis treated in our department from 1986 to 2010. Delayed OE was performed on 71 (4,8%) pts. Seminoma — 8 pts (11,2%), nonseminomatous tumor — 50 pts (70,4%), unknown histology — 13 pts (18,4%). OE was performed on 39 (55%) pts during cycle 1, 11 (15,5%) pts — after completion of induction CT, other pts — during cycles 2–4. Median f.— up time was 156 (range, 3–245) months
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