Abstract
BackgroundThe aim of this study was to examine the effect of thyroid-stimulating hormone (TSH) levels on intrauterine insemination (IUI) outcomes among euthyroid women.MethodsA retrospective cohort study was conducted. A total of 302 women who started their first IUI cycle in our fertility center were included in this study. The patients were categorized into two groups based on their preconception TSH values: 0.38–2.49 mIU/Land 2.50–4.99 mIU/L. The clinical pregnancy rate was the main outcome parameter. As secondary parameters, we evaluated the differences in spontaneous abortion rate, live-birth delivery rate, and perinatal outcomes according to the preconception TSH threshold (< 2.5 and < 5.00 mIU/L).ResultsThere was no significant difference between the two groups with respect to clinical pregnancy, miscarriage, and live-birth rates with an odds ratio of 1.67 (95% CI: 0.79–3.53), 1.08 (95% CI: 0.09–13.1), and 1.79 (95% CI: 0.77–4.2), respectively. In addition, there were no significant differences in perinatal outcomes (gestation at delivery, birth weight, and neonatal intensive care unit–administration rate) between the two groups.ConclusionsOur findings indicate that among euthyroid patients, preconception TSH values in the high-normal range (between 2.5 and 4.9 mIU/L) do not have a negative effect on IUI outcomes.Trial registrationThis study is retrospectively registered by Ethical Review Board at Inonu University in 19th December 2017; Ethics approval no is 2017–27-20.
Highlights
The aim of this study was to examine the effect of thyroid-stimulating hormone (TSH) levels on intrauterine insemination (IUI) outcomes among euthyroid women
The first documented application of artificial insemination in humans was done in the 1770s by John Hunter [1], and intrauterine insemination (IUI) is the first-line treatment in couples with unexplained infertility, cervical factors–related infertility, ejaculatory abnormalities, and male subfertility [2]
A total of 302 women who underwent their first IUI cycles were included in the analysis
Summary
The aim of this study was to examine the effect of thyroid-stimulating hormone (TSH) levels on intrauterine insemination (IUI) outcomes among euthyroid women. The first documented application of artificial insemination in humans was done in the 1770s by John Hunter [1], and intrauterine insemination (IUI) is the first-line treatment in couples with unexplained infertility, cervical factors–related infertility, ejaculatory abnormalities, and male subfertility [2]. Thyroid disorders are one of the most common endocrine conditions affecting women during their reproductive age [3]. Thyroid disorders are associated with a number of adverse reproductive outcomes, including. The present study was Tuncay et al BMC Women's Health (2018) 18:51 aimed at assessing the relative importance of TSH levels on the outcomes of women undergoing IUI
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