The impact of therapeutic regimen on the depression in type 2 diabetes mellitus: A cross-sectional study

Abstract

To explore the depression in type 2 diabetic patients treated with insulin and compared to those treated with oral anti-diabetic drugs. 283 type 2 diabetics were seclected randomly from outpatient and inpatient departments of endocrionology in Jiangsu Province Hospital of Traditional Chinese Medicine, with the self-designed questionnaire and Zung self-rating depression scale to conduct the survey. Comparisons between the two groups were carried out with t-test or χ2test for quantitative and qualitative data, respectively. Logistic regression were used for the analysis of the relationship between the therapeutic regimen and depression. Overall, 43.1% of the type 2 diabetic subjects showed depressive symptoms in different degrees. Compared to the oral drug group, the insulin group showed a significantly higher prevalence of depressive symptoms(insulin group, 53.5%, oral drug group, 30.5%; P<0.01)and higher self-rating depression scale scores(insulin group, 51.7±12.4, oral drug group, 44.8±10.6; P<0.01). Moreover, after an adjustment for age, sex, body mass index, diabetic duration, complications, HbA1Cand so on, the insulin group showed a significantly higher frequency of depression(OR=4.218, 95%CI 1.764-13.285, P=0.004), compared to the oral drug group. The data showed that insulin treatment is an independent risk factor to the presence of depressive symptoms in type 2 diabetics, and it is necessary to pay more attention to their psychological support. (Chin J Endocrinol Metab, 2015, 31: 346-348) Key words: Diabetes mellitus, type 2; Depression; Insulin; Oral drugs