The impact of temperature and decay in insecticide-treated net efficacy on malaria prevalence and control

Abstract

Insecticide-treated nets (ITNs) have been useful and effective in mitigating the risk of malaria globally. However, due to misuse and normal/human-induced physical and chemical wear, the effectiveness of ITNs in combating malaria has been declining. Underlying heterogeneities in the nature of malaria, combined with environmental factors such as temperature lead to complex malaria transmission and control dynamics. In particular, temperature plays a significant role in determining the risk of malaria since it influences the growth and survival of mosquitoes and the malaria parasite. Here, a unifying mechanistic framework that integrates malaria dynamics with waning ITN-efficacy and temperature change is developed and used to assess the impact of interactions between significant sources of variation (e.g., temperature) and waning ITN-efficacy on the risk of malaria transmission and the success of ITN programs. The model exhibits a backward bifurcation when ITN-efficacy is constant implying that control efforts must be stepped up and sustained a bit longer even when the reproduction number is slightly less than one. The study shows that malaria is more effectively controlled with ITNs that have a longer lifespan and if ITNs are replaced before the end of their expiration period. Also, failing to account for waning ITN-efficacy leads to an underestimation of disease risk, burden, and effort level required to contain the disease. Local and global sensitivity analyses show that control and temperature-related parameters are primary drivers of the reproduction number and the human disease burden, highlighting the significance of temperature on malaria dynamics. Furthermore, the study shows that the human disease burden is optimal at a temperature of ≈28°C and that high seasonal variations can trigger major malaria outbreaks even in regions with low mean temperatures. Additionally, accounting for both seasonality and decay in ITN-efficacy leads to complex malaria patterns. To sum it up, insights into the sensitivity of malaria dynamics on temperature are useful in assessing the potential impact of changes in temperature on malaria risk. Also, a malaria control program, which ensures that ITNs are replaced regularly and early enough, and that educates at risk populations on proper use and care for ITNs is necessary for reducing the burden of malaria.