Abstract
Objective To explore the impact of splenectomy on the blood routine examination in a patient with primary myelofibrosis (PMF) and megalosplenia. Methods Splenectomy was performed on a patient diagnosed with PMF and megalosplenia.Blood routine examinations were dynamically observed and histological examination was performed on the spleen. Results After splenectomy, the symptoms of dyspnea, abdominal distension and inappetence improved markedly.Leukocyte increased significantly.The percentage of neutrophils decreased while the percentage of lymphocytes increased.The change of erythrocyte was not obvious.Due to autologous blood transfusion, hemoglobin increased immediately after surgery, and then returned to normal level.Platelet fell to 10×109/L, and then increased gradually to normal level.Histological examination demonstrated that the spleen showed myeloid metaplasia. Conclusions Blood routine examination changes significantly after splenectomy is performed on the patient diagnosed with PMF and megalosplenia.The spleen shows certain bone marrow hematopoietic function.After splenectomy, the hematopoietic ability can still meet the need of the body.Thus, splenectomy should be performed on patients with injured respiratory and digestive function due to PMF-caused megalosplenia. Key words: Primary myelofibrosis; Splenomegaly; Splenectomy; Blood routine examination
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