Abstract
Background: Elective liver surgery represents an important cornerstone in the treatment of patients suffering from colorectal liver metastases (CRCLM). To improve resectability in those patients, neoadjuvant chemotherapy (NAC) is frequently utilized. However, NAC induces chemotherapy associated steatohepatitis (CASH). The extent of CASH induction can greatly vary between patients, and some appear particularly receptive to this side effect. CASH has been shown to result in postoperative failure of hepatic regeneration/recovery, greatly affecting overall patients’ outcome. Although testing for certain gene mutations is part of the preparations for adequate treatment, single nucleotide polymorphisms (SNPs) have not been sufficiently assessed in this scenario. Through a difference in one single base position in the DNA, SNPs are in some cases responsible for an altered cell metabolism. This can be observed in genetic variants such as the rs738409 polymorphism in the patatin-like phospholipase domain containing protein 3 gene (PNPLA3 I148M), which is closely associated with progression of chronic liver disease.
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