Abstract
Background: Zinc deficiency is highly prevalent and is caused by inadequate dietary intake, malabsorption and removal by treatment in hemodialysis patients. This study investigated the relationship between serum zinc levels and nutritional status in hemodialysis patients. Methods: A cross-sectional study examining 87 hemodialysis patients was performed. The serum concentrations of zinc were studied to evaluate their association with nutritional status, which was assessed by measuring abdominal muscle and fat areas with computed tomography. Results: Serum zinc levels were significantly and positively correlated with subcutaneous and visceral fat areas (r = 0.299, p < 0.01, and r = 0.298, p < 0.01, respectively), but not abdominal muscle areas. Multiple regression analyses demonstrated that serum zinc levels were a significant independent predictor of visceral fat areas (p < 0.01), but not subcutaneous fat areas (p = 0.631). Conclusions: Our findings suggest that serum zinc levels could play a crucial role in determining abdominal fat mass in hemodialysis patients.
Highlights
Zinc is an essential trace element for human nutrition, and its deficiency is associated with growth retardation, anorexia, insulin resistance, and impaired immune systems [1,2]
No significant sex differences were observed with respect to the age, dialysis vintage, body mass index (BMI), Charlson comorbidity index, serum albumin, calcium, phosphate, zinc, and copper levels
The patient height, dry weight, and serum Cr levels were significantly greater in men than in women, whereas total cholesterol and LDL cholesterol levels were significantly greater in women than in men
Summary
Zinc is an essential trace element for human nutrition, and its deficiency is associated with growth retardation, anorexia, insulin resistance, and impaired immune systems [1,2]. Patients undergoing hemodialysis (HD) have been reported to have low serum concentrations of zinc due to inadequate dietary intake, reduced gastrointestinal absorption, and zinc removal during HD sessions [3,4]. Zinc deficiency is highly prevalent and is caused by inadequate dietary intake, malabsorption and removal by treatment in hemodialysis patients. This study investigated the relationship between serum zinc levels and nutritional status in hemodialysis patients. The serum concentrations of zinc were studied to evaluate their association with nutritional status, which was assessed by measuring abdominal muscle and fat areas with computed tomography. Conclusions: Our findings suggest that serum zinc levels could play a crucial role in determining abdominal fat mass in hemodialysis patients
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