Abstract
Serum uric acid (SUA) level has been proposed to have important connections with chronic kidney disease (CKD), while the impact of SUA level on the natural history of glomerular filtration rate (GFR) decline remains unknown. The present study aims to study the association of the SUA level with the GFR decline in a general population. Two thousand, seven hundred and eighty-nine subjects who visited the Health Checkup Clinic both at 2008 and 2013 were identified. A significant inverse correlation was observed between change in SUA from 2008–2013 (ΔSUA) and change in eGFR (ΔeGFR) during the same period. Multivariate regression analysis of ΔeGFR indicated that the increase in SUA over time were a negative predictor of the change in eGFR. Our result indicates that the decline of eGFR over years is larger in subjects with an increased SUA level, which helps to underline the importance of SUA level management in the context of kidney function preservation.
Highlights
Uric acid (UA) is a poorly soluble end product of purine nucleotides degradation, and hyperuricemia is defined as serum uric acid (SUA) level >420 umol/L (7 mg/dl) in males and >360 umol/L (>6 mg/dl) in females (Chuang et al, 2012)
The present study aims to study the association of the SUA level with the glomerular filtration rate (GFR) decline in a general population who visited the Health Checkup Clinic regularly, and our results suggested a role of SUA level in the GFR decline
The SUA level was significantly increased from year 2008–2013 (322.00 (382.00, 267.00) versus 352.00 (410.00, 295.00) umol/L, p < 0.01)
Summary
Uric acid (UA) is a poorly soluble end product of purine nucleotides degradation, and hyperuricemia is defined as serum uric acid (SUA) level >420 umol/L (7 mg/dl) in males and >360 umol/L (>6 mg/dl) in females (Chuang et al, 2012). Recent researches have suggested SUA to be an independent risk factor for cardiovascular disease (Chuang et al, 2012) and metabolic syndrome (MetS) (Liu et al, 2014; Nejatinamini et al, 2015). Hyperuricemia was suggested to be associated with the onset of type 2 diabetes mellitus (DM) (Miyake et al, 2014) and stroke (Qin et al, 2014). As long as the kidney is concerned, the pathophysiological role of SUA in the chronic kidney disease (CKD) has attracted a lot of nephrologists and there are many studies published. It has been established that in patients with gout and acute UA nephropathy, the treatment of hyperuricemia is of clinical benefits.
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