Abstract
Objective: It is well known that natural conception rate changes with seasonal variations. There are controversial findings in the literature regarding the impact of seasonal variations on pregnancy rates during IVF. The aim of this study was to investigate relationship between seasonal variations and pregnancy rates in patients undergoing ICSI. Design: Retrospevtive study. Materials and Methods: All patients undergoing their first ICSI cycles were evaluated retrospectively. We divided patients into four groups: Group I: Patients underwent ICSI from 1st of December to the last day of February; Group II: ICSI cycles performed between 1st of March to 31st of May; Group III: ICSI cycles performed between 1st of June and 31st of August; Group IV: ICSI cycles performed between 1st of July and 3oth of November. Fertilization rate, embryo quality and pregnancy rate were evaluated. Statistical analysis was made using One Way ANOVA, Student T-test and Chi-Square test and a p value less than 0,05 was accepted as significant. Results: As shown in table I there was no difference regarding age of patients, duration of infertility, duration of stimulation, number of ampules used, E2 levels on the day of hCG, number of eggs retrieved, fertilization and pregnancy rates. Number of grade I embryos and number of embryos transferred were significantly higher in group II (spring time). Tabled 1 Conclusion: Although number of grade I embryos are significantly higher during spring time, it does not seem to affect, clinical outcome. This may be due to low number of grade I embryos in all groups. Also number of embryos transferred were significantly higher during spring time, it has no clinical significance possibly due to our transfer policy of at least three embryos in the past.In conclusion we can say that seasonal variations has no influence on the clinical outcome in patients undergoing ICSI.
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