Abstract
Background and Objective Drug dependence is one of the serious problems around the world. Saffron is one of those beneficial medicinal plants which is embedded with a similar mechanism to methadone (e.g., inhibition of serotonin reuptake). Thus, it can be helpful in reducing the withdrawal symptoms. The aim of this study was to reduce the daily dose of methadone usage and reduce its side effects using saffron in the form of medicinal supplements. Methodology This study was categorized as a clinical trial. Accordingly, 44 clients of addiction treatment centers in Sabzevar parish were randomly selected to participate in this study in 2016–2017. While the experimental group was treated with methadone syrup and self-made saffron capsules, the control group received methadone syrup and placebo capsules. Results The results showed that the use of saffron and methadone alleviated the symptoms of withdrawal syndrome (p<0.001). Conclusion Having reviewed the research participants, it was indicated that the introduction of saffron alleviated the symptoms of withdrawal syndrome in patients undergoing maintenance treatment for opioid addiction. Thus, it seems rational to make use of saffron in combination with methadone in order to alleviate the symptoms of withdrawal syndrome.
Highlights
Nowadays, the main mechanisms and brain-driven factors that are associated with opioid dependence are known to a large extent
The main mechanisms and brain-driven factors that are associated with opioid dependence are known to a large extent. It seems that the dopamine mesocorticolimbic pathway is one of the most important pathways associated with drug dependence that play an important and vital role in psychological dependence to opioids [1]. is pathway starts from the ventral tegmental area, which is considered the A10 dopamine neurons, and ends in nucleus accumbens, frontal cortex, and other areas involved in memory, such as the hippocampus and amygdala
E results showed that the status of subjects in connection to withdrawal symptoms might be depicted in terms of Figures 1 and 2
Summary
The main mechanisms and brain-driven factors that are associated with opioid dependence are known to a large extent. It seems that the dopamine mesocorticolimbic pathway is one of the most important pathways associated with drug dependence that play an important and vital role in psychological dependence to opioids [1]. E results showed that the use of sa ron and methadone alleviated the symptoms of withdrawal syndrome (p < 0.001). Having reviewed the research participants, it was indicated that the introduction of sa ron alleviated the symptoms of withdrawal syndrome in patients undergoing maintenance treatment for opioid addiction. Us, it seems rational to make use of sa ron in combination with methadone in order to alleviate the symptoms of withdrawal syndrome Having reviewed the research participants, it was indicated that the introduction of sa ron alleviated the symptoms of withdrawal syndrome in patients undergoing maintenance treatment for opioid addiction. us, it seems rational to make use of sa ron in combination with methadone in order to alleviate the symptoms of withdrawal syndrome
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