The impact of polymers’ supramolecular structure on water vapour sorption and drug release from films on the basis of some polysaccharide

Abstract

The article establishes the relationship between supramolecular film structure of some polysaccharides and their diffusion characteristics. The differences in the supramolecular film structures, in their turn, are associated with the differences in the structural-physical state of the solutions the films are made from and the time of the film dry out. It was established that in a definite area of concentrations of polymer solutions there was a sharp increase in viscosity due to the interaction of the macromolecular chains and mass scale formation of molecular aggregates in the solution. As a result, the polysaccharide solutions of different concentration differ from the structural-physical point of view. It was proved that the polymer concentration in the initial solution contributes greatly to the structure of the films formed, and the changes in the supramolecular structure of the film samples have an impact on the diffusion characteristics. It was established that the values of the diffusion coefficients determined in the experiments depend on the polymer concentration in the initial solution and the thickness of the film samples. It was also showed that the diffusion processes do not follow the Fick's law and occur in an abnormal diffusion mode.