THE IMPACT OF ORAL AND OROPHARYNGEAL CANCER PATIENT'S MEDICAL PROFILE ON TREATMENT-RELATED TOXICITIES.

Abstract

Objective To characterize oral and oropharyngeal squamous cell carcinoma (OOPSCC) patients with dental needs before cancer treatment. Patient's pre-oncological treatment data, including medical and sociodemographic characteristics, and laboratory tests results, were correlated with treatment-related head and neck toxicities. Study Design A prospective cohort study. Results 110 patients were included. The most common comorbidities were hypertension, dyslipidemia, and diabetes. C-reactive protein, hemoglobin, and hematocrit were the most altered tests results. Toxicities were progressive over time. There was a positive correlation (0.268) between the number of medications and oral mucositis (OM), and a negative correlation (-0.257) between medications and dysgeusia. For OM, altered exams showed significative P-values: thyroxine (T4) and free thyroxine (FT4) starting at D15; calcium at D5/10/30; urea at D25/30/33-35; creatinine at D15/30; alkaline phosphatase at D20/25; syphilis at D15/30. Family income and housing were OM predictors. Oral candidiasis (OC) was associated with syphilis and HIV at D20. Conclusion OOPSCC patients have several comorbidities and abnormal laboratory results. No dental treatment before cancer treatment resulted in adverse events. Laboratory findings of altered T4, FT4, urea, calcium, alkaline phosphatase, creatinine, and syphilis may be useful predictors of OM. Syphilis and HIV may also be predictors of OC secondary to OOPSCC treatment. To characterize oral and oropharyngeal squamous cell carcinoma (OOPSCC) patients with dental needs before cancer treatment. Patient's pre-oncological treatment data, including medical and sociodemographic characteristics, and laboratory tests results, were correlated with treatment-related head and neck toxicities. A prospective cohort study. 110 patients were included. The most common comorbidities were hypertension, dyslipidemia, and diabetes. C-reactive protein, hemoglobin, and hematocrit were the most altered tests results. Toxicities were progressive over time. There was a positive correlation (0.268) between the number of medications and oral mucositis (OM), and a negative correlation (-0.257) between medications and dysgeusia. For OM, altered exams showed significative P-values: thyroxine (T4) and free thyroxine (FT4) starting at D15; calcium at D5/10/30; urea at D25/30/33-35; creatinine at D15/30; alkaline phosphatase at D20/25; syphilis at D15/30. Family income and housing were OM predictors. Oral candidiasis (OC) was associated with syphilis and HIV at D20. OOPSCC patients have several comorbidities and abnormal laboratory results. No dental treatment before cancer treatment resulted in adverse events. Laboratory findings of altered T4, FT4, urea, calcium, alkaline phosphatase, creatinine, and syphilis may be useful predictors of OM. Syphilis and HIV may also be predictors of OC secondary to OOPSCC treatment.