Abstract
359 Background: Increasing the number of cycles of cetuximab and bevacizumab in metastatic colorectal cancer might limit affordability and impact cost-effevctiveness. Methods: Average wholesale prices (AWPs) in U.S. dollars (US $) of cetuximab and bevacizumab were divided by reported median survival gain in days. Cost/survival of 90% of drugs was <$750. A reference scale between 0% and 100% was constructed with 0% assigned to cost/overall survival (OS) > $750, life threatening/fatal adverse events (AEs) and worsened quality of life (QoL). A plan was designed to correct for AEs and QoL. Results: Expressed as cost/overall survival (OS), crude and corrected scores (Table). Conclusions: Increasing number of cycles of cetuximab and bevacizumab increased the cost/survival and decreased scores. A limit on the purchase price of the entire treatment course of targeted therapy is recommended. [Table: see text]
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