Abstract
Glutamatergic dysfunction and immune system dysregulation are both thought to be involved in the pathophysiology of depression. One potential convergence point for these systems is the kynurenine (KYN) pathway. Notably, ketamine has rapid-acting and sustained antidepressant properties. 7-chlorokynurenic acid is a NMDA antagonist at glycine binding site Its prodrug, AV-101 is assumed to efficiently cross the blood-brain barrier and convert to 7-chlorokynurenic acid in the brain.
Full Text 
Sign-in/Register to access full text options
Sign-in/Register to access full text options 
Published version (
Free)
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
