The impact of modulators of nitric oxide synthesis on biochemical indices of liver in rats

Abstract

In experiments on white male rats it was shown that repeated administrations of nitric oxide precursors L-arginine and L-arginine L-glutamate do not alter the activity of cytolysis enzymes, reduce lipid peroxidation that correlates with indices of antioxidant protection, increase enzymatic activity in mitochondria and reduce endotoxemia. NO-synthase blockade by L-NAME increases endotoxemia, inhibits detoxification process in the liver, reduces the activity of electron transport enzymes in mitochondria, activation of lipids peroxodation reducing protective reserves of antioxidant system that is accompanied by low levels of NO2- in blood and liver.