Abstract
Particle breakage by attrition is unavoidable in some unit operations and can lead to uncontrolled behavior of materials during processing. The aim of this study is to clarify the impact of material properties on attrition behavior. For the first time, an integral study with varying morphologies and chemistries is performed to identify the key drivers that impact attrition during high shear blending. Based upon the observed changes in particle size distribution, it was concluded that dicalcium phosphate (DCP) was the most prone to attrition, followed by mannitol, lactose and microcrystalline cellulose (MCC). Granular particles were more sensitive to attrition than sieved and spherical particles. Changes in bulk density, flow function coefficient and tablet tensile strength were observed as the result of attrition. The magnitude and direction of change in these parameters was not only dependent on the amount of attrition, but also on the morphology and the material deformation properties.
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