Abstract
BackgroundTo assess the impact of luteal phase support on the expression of estrogen receptor (ER) alpha and progesterone receptors B (PR-B) on the endometrium of oocyte donors undergoing controlled ovarian hyperstimulation (COH).MethodsA prospective, randomized study was conducted in women undergoing controlled ovarian hyperstimulation for oocyte donation. Participants were randomized to receive no luteal support, vaginal progesterone alone, or vaginal progesterone plus orally administered 17 Beta estradiol. Endometrial biopsies were obtained at 4 time points in the luteal phase and evaluated by tissue microarray for expression of ER alpha and PR-B.ResultsOne-hundred and eight endometrial tissue samples were obtained from 12 patients. No differences were found in expression of ER alpha and PR-B among all the specimens with the exception of one sample value.ConclusionsThe administration of progesterone during the luteal phase of COH for oocyte donor cycles, either with or without estrogen, does not significantly affect the endometrial expression of ER alpha and PR.
Highlights
To assess the impact of luteal phase support on the expression of estrogen receptor (ER) alpha and progesterone receptors B (PR-B) on the endometrium of oocyte donors undergoing controlled ovarian hyperstimulation (COH)
Some investigators purport that controlled ovarian hyperstimulation (COH) protocols inevitably lead to lack of synchrony between the development and maturation of the endometrium and the time of oocyte retrieval or “ovulation” [3,4]
No difference was found in baseline laboratory values, including follicle stimulating hormone (FSH) and E2 levels on CD#2, or the total injectable medications used among the groups
Summary
To assess the impact of luteal phase support on the expression of estrogen receptor (ER) alpha and progesterone receptors B (PR-B) on the endometrium of oocyte donors undergoing controlled ovarian hyperstimulation (COH). There are some data showing that, in GnRH agonist/HMG stimulated cycles, lack of supplementation with exogenous progesterone (P) results in impaired P bioavailability [9,10]. For this reason, luteal phase support is customarily used to improve endometrial structure and histology facilitating the implantation process. P is accepted as the preferred agent for luteal phase support and is administered orally, intramuscularly, or vaginally [11,12]
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