The impact of low-risk genetic variants in self-limited epilepsy with centrotemporal spikes aka Rolandic epilepsy.

Abstract

Epilepsy is a common neurological disorder with a lifetime prevalence of 3%–4%. The disorder is defined by recurrent, unprovoked seizures resulting from abnormal, synchronized neuronal firing in the brain and encompasses a heterogeneous group of disease entities with diverse etiologies and outcomes. Genetic factors are known to play a significant role in epilepsy, either as monogenic causes in rare Mendelian epilepsies, or as multiple genetic risk factors in common epilepsies such as genetic generalized and focal epilepsies.